Acute Cutaneous Lupus Erythematosus (ACLE) is often seen in patients with active systemic disease. Flat red patches on the cheeks and nose called a butterfly rash that looks quite like sunburn characterize the most common form of ACLE. Individuals may also present with generalized flat red patches on arms, legs and trunk. These lesions are sensitive to the sun (photosensitive to both sun rays and tanning rays) and therefore commonly appear on sun-exposed areas. While these lesions do not often result in scarring, they may leave dark or light pigment changes. Other lesions associated with ACLE include oral ulcers, hives, and temporary hair loss, which are replaced by new hair once the disease flare is treated.

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